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pentobarbital will minimize the extent or effect of fedratinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Outcome of coadministering a solid CYP3A4 inducer with fedratinib hasn't been analyzed.pentobarbital will reduce the extent or effect of methadone by impacting hepatic/intestinal enzyme CYP3A4 metab